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ATLANTA - All Americans between the ages of 13 and 64 should be routinely tested for HIV to help catch infections earlier and stop the spread of the deadly virus, federal health recommendations announced Thursday say.
The U.S. Centers for Disease Control and Prevention said HIV testing should become about as common as a cholesterol check. Nearly half of new HIV infections are discovered when doctors are trying to diagnose a sick patient who has come for care, CDC officials said.
“We know that many HIV infected people seek health care and they don’t get tested. And many people are not diagnosed until late in the course of their illness, when they’re already sick with HIV-related conditions,” said Dr. Timothy Mastro, acting director of the CDC’s division of HIV/AIDS prevention.
“By identifying people earlier through a screening program, we’ll allow them to access life-extending therapy, and also through prevention services, learn how to avoid transmitting HIV infection to others,” he said.
The announcement was hailed by some HIV patient advocates and health policy experts. They said the guidelines could help end the stigma of HIV testing and lead to needed care for an estimated 250,000 Americans who don’t yet know they have the disease.
“I think it’s an incredible advance. I think it’s courageous on the part of the CDC,” said A. David Paltiel, a health policy expert at the Yale University School of Medicine.
The recommendations aren’t legally binding, but they influence what doctors do and what health insurance programs cover.
Some physicians groups predict the recommendations will be challenging to implement, involving new expenditures of money and time for testing, counseling and revising consent procedures.
Some physicians also question whether there is enough evidence to expand testing beyond high-risk groups, said Dr. Larry Fields, the president of the American Academy of Family Physicians.
“Are doctors going to do it? Probably not,” Fields said.
But the recommendations were endorsed by the American Medical Association, which urged physicians to comply.
“This is important public health strategy to stop the spread of HIV,” Dr. Nancy Nielsen, a Buffalo, N.Y.-based physician who sits on the AMA’s governing board, said in a statement.
No consent form neededPreviously, the CDC recommended routine testing for those at high-risk for catching the virus, such as intravenous drug users and gay men, and for hospitals and certain other institutions serving areas where HIV is common. It also recommends testing for all pregnant women.
Under the new guidelines, patients would be tested for HIV as part of a standard battery of tests they receive when they go for urgent or emergency care, or even during a routine physical.
Patients wouldn’t get tested every year: Repeated, annual testing would only be recommended only for those at high-risk.
There would be no consent form specifically for the HIV test; it would be covered in a clinic or hospital’s standard care consent form. Patients would be allowed to decline the testing.
CDC officials have been working on revised recommendations for about three years, and sought input from more than 100 organizations, including doctors’ associations and HIV patient advocacy groups. The CDC presented planned revisions at a scientific conference in February.
Since then, the CDC has strengthened language on informed consent to make sure that no one is tested without their knowledge, and emphasized the need for doctors to provide information on HIV tests and the meaning of positive and negative results.
© 2006 The Associated Press.
Thursday, September 21, 2006
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Why do some with HIV not get sick?
Doctors want to test DNA of thousands of U.S. patients who never got ill
TORONTO - As many as one in 300 HIV patients never get sick and never suffer damage to their immune systems and AIDS experts said Wednesday they want to know why.
Most have gone unnoticed by the top researchers, because they are well, do not need treatment and do not want attention, said Dr. Bruce Walker of Harvard Medical School.
But Walker and colleagues want to study these so-called “elite” patients in the hope that their cases can help in the search for a vaccine or treatments.
“What in the heck is going on in people that successfully control this virus?” Walker asked a news conference held at the 16th International Conference on AIDS.
“If we can figure out how people are doing that, we can try to replicate it.”
So far Walker and colleagues have not been able to find out why certain people can live for 15 years and longer with the virus and never get ill. The AIDS virus usually kills patients within two years if they are not treated.
Some even appear to have weak immune responses, he noted. “Is it just that these people got infected with a wimpy virus? The answer to that is no,” Walker said.
“Some of the people know who infected them,” he added, and in those cases, the person who infected the “elite” patients always went on to become ill.
A few years into the AIDS epidemic, researchers identified people who were called “long-term non-progressors.” These were patients infected with HIV who did not become ill.
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Many have become ill as the years have gone by, and required treatment.
Walker said a few of the long-term non-progressors were now classified as “elite” patients. But the difference is that the “elite” status is clearly defined by how much virus they have circulating in their blood.
Loreen Willenberg, of Diamond Springs, California, is a newly designated “elite.” Now 52 and healthy, she said she became infected in 1992.
Bad dream
“I dreamed that I was HIV positive,” Willenberg told the news conference.
“I was really going through a very bad flu.” She sought testing, and after getting an inconclusive result was later declared HIV positive.
HIV patients are not immediately put onto drugs that can keep them healthy, but wait until the virus reaches a certain level in the blood or until the virus kills a certain number of immune system cells called CD4 T-cells.
Willenberg, a landscape designer, never got to that point.
“I am in perfect health. I think I have had maybe only one cold in the past 14 years,” she said.
Walker has tracked down 200 elite patients and has now joined up with other prominent AIDS researchers to find at least 1,000 “elites” in North America and as many as possible globally.
Based on research done so far, Walker estimates there are 2,000 of them in the United States.
His team wants to take blood and DNA samples to see what might be different about them. Confidentiality is promised.
The recently published map of the human genome will make this possible.
They will compare key genetic sequences of the “elite” patients to genetic readouts from healthy people and from other HIV patients. Maybe a few genetic variations can explain what is happening, Walker hopes.
Copyright 2006 Reuters Limited
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